| 2026 | Shortlist | Bad Influence: How the Internet Hijacked our Health | Deborah Cohen | Unknown |
| 2026 | Shortlist | Despite it All: A Handbook for Climate Hopefuls | Fred Pearce | Unknown |
| 2026 | Shortlist | Every Last Fish: What Fish Do for Us and What We Do to Them | Rose George | Unknown |
| 2026 | Shortlist | Hidden Guests: Migrating Cells and How the New Science of Microchimerism is Redefining Human Identity | Lise Barnéoud | Unknown |
| 2026 | Shortlist | How to Change a Memory: One Neuroscientist's Quest to Alter the Past | Steve Ramirez | Unknown |
| 2026 | Shortlist | The Age of Alchemy: How Early Innovators Shaped Modern Chemistry | Kit Chapman | Unknown |
| 2025 | Winner | Our Brains, Our Selves: What a Neurologist's Patients Taught Him About the Brain | Masud Husain | Canongate |
| 2025 | Shortlist | Ends of the Earth: Journeys to the Polar Regions in Search of Life, the Cosmos, and our Future | Neil Shubin | Penguin Publishing Group |
| 2025 | Shortlist | Music as Medicine: How We Can Harness Its Therapeutic Power | Daniel Levitin | Unknown |
| 2025 | Shortlist | The Forbidden Garden of Leningrad: A True Story of Science and Sacrifice in a City under Siege | Simon Parkin | Hodder & Stoughton |
| 2025 | Shortlist | Vanished: An Unnatural History of Extinction | Sadiah Qureshi | Penguin Books |
| 2025 | Shortlist | Your Life is Manufactured: How We Make Things, Why It Matters and How We Can Do It Better | Tim Minshall | Unknown |
| 2024 | Winner | A City on Mars: Can We Settle Space, Should We Settle Space, and Have We Really Thought This Through? | Zach Weinersmith, Kelly Weinersmith | Penguin Press |
| 2024 | Shortlist | Eve: How the Female Body Drove 200 Million Years of Human Evolution | Cat Bohannon | Knopf |
| 2024 | Shortlist | Everything Is Predictable: How Bayes' Remarkable Theorem Explains the World | Tom Chivers | Orion |
| 2024 | Shortlist | The Last of Its Kind: The Search for the Great Auk and the Discovery of Extinction | Gísli Pálsson | Unknown |
| 2024 | Shortlist | Why We Die: The New Science of Ageing and the Quest for Immortality | Venki Ramakrishnan | HarperCollins |
| 2024 | Shortlist | Your Face Belongs to Us: The Secretive Startup Dismantling Your Privacy | Kashmir Hill | Simon & Schuster |
| 2023 | Winner | An Immense World: How Animal Senses Reveal the Hidden Realms Around Us | Ed Yong | Random House |
| 2023 | Shortlist | Breathless: The Scientific Race to Defeat a Deadly Virus | David Quammen | Simon & Schuster |
| 2023 | Shortlist | Jellyfish Age Backwards: Nature's Secrets to Longevity | Nicklas Brendborg | Little, Brown |
| 2023 | Shortlist | Nuts and Bolts: Seven Small Inventions That Changed the World (in a Big Way) | Roma Agrawal | Unknown |
| 2023 | Shortlist | Taking Flight: The Evolutionary Story of Life on the Wing | Lev Parikian | Elliott & Thompson |
| 2023 | Shortlist | The Exceptions: Nancy Hopkins, MIT, and the Fight for Women in Science | Kate Zernike | Scribner |
| 2022 | Winner | A (Very) Short History of Life on Earth: 4.6 Billion Years in 12 Pithy Chapters | Henry Gee | Unknown |
| 2022 | Shortlist | Age Proof: The New Science of Living a Longer and Healthier Life | Rose Anne Kenny | Unknown |
| 2022 | Shortlist | Different: What Apes Can Teach Us About Gender | Frans de Waal | Granta Books |
| 2022 | Shortlist | Hot Air: The Inside Story of the Battle Against Climate Change Denial | Peter A. Stott | Atlantic Books |
| 2022 | Shortlist | Spike: The Virus vs. The People – the Inside Story | Jeremy Farrar, Anjana Ahuja | Unknown |
| 2022 | Shortlist | The Greywacke: How a Priest, a Soldier and a School Teacher Uncovered 300 Million Years of History | Nick Davidson | Unknown |
| 2021 | Winner | Entangled Life | Merlin Sheldrake | Random House Trade Paperbacks |
| 2021 | Shortlist | Breath | James Nestor | Penguin Publishing Group |
| 2021 | Shortlist | Science Fictions | Stuart J. Ritchie | Unknown |
| 2021 | Shortlist | The End of Bias: A Beginning: The Science and Practice of Overcoming Unconscious Bias | Jessica Nordell | Macmillan |
| 2021 | Shortlist | The Last Stargazers: The Enduring Story of Astronomy’s Vanishing Explorers | Emily Levesque | Sourcebooks |
| 2021 | Shortlist | The Sleeping Beauties | Suzanne O'Sullivan | Picador |
| 2020 | Winner | Explaining Humans | Camilla Pang | Penguin Books |
| 2020 | Shortlist | The Body: A Guide for Occupants | Bill Bryson | Anchor |
| 2020 | Shortlist | The Double X Economy | Linda Scott | Farrar, Straus and Giroux |
| 2020 | Shortlist | The Great Pretender | Susannah Cahalan | Grand Central Publishing |
| 2020 | Shortlist | The World According to Physics | Jim Al-Khalili | Princeton University Press |
| 2020 | Shortlist | Transcendence | Gaia Vince | Penguin Books |
| 2019 | Winner | Infinite Powers | Steven Strogatz | Mariner Books |
| 2019 | Winner | Invisible Women: Exposing Data Bias in a World Designed for Men | Caroline Criado-Perez | Chatto & Windus |
| 2019 | Shortlist | Clearing the Air | Tim Smedley | Bloomsbury |
| 2019 | Shortlist | Six Impossible Things | John Gribbin | MIT Press |
| 2019 | Shortlist | The Remarkable Life of the Skin | Monty Lyman | Unknown |
| 2019 | Shortlist | The Second Kind of Impossible | Paul Steinhardt | Unknown |
| 2018 | Winner | Inventing Ourselves: The Secret Life of the Teenage Brain | Sarah-Jayne Blakemore | PublicAffairs |
| 2018 | Shortlist | Exactly: How Precision Engineers Created the Modern World | Simon Winchester | William Collins |
| 2018 | Shortlist | Hello World: How to Be Human in the Age of the Machine | Hannah Fry | Doubleday |
| 2018 | Shortlist | Liquid: The Delightful and Dangerous Substances That Flow Through Our Lives | Mark Miodownik | Unknown |
| 2018 | Shortlist | The Beautiful Cure: Harnessing Your Body’s Natural Defences | Daniel M. Davis | The Bodley Head |
| 2018 | Shortlist | The Unexpected Truth About Animals | Lucy Cooke | Transworld |
| 2017 | Winner | Testosterone Rex: Unmaking the Myths of Our Gendered Minds | Cordelia Fine | W. W. Norton |
| 2017 | Shortlist | Beyond Infinity: An Expedition to the Outer Limits of the Mathematical Universe | Eugenia Cheng | Basic Books |
| 2017 | Shortlist | I Contain Multitudes: The Microbes Within Us and a Grander View of Life | Ed Yong | Vintage Books |
| 2017 | Shortlist | In Pursuit of Memory: The Fight Against Alzheimer's | Joseph Jebelli | Little, Brown |
| 2017 | Shortlist | Other Minds: The Octopus and the Evolution of Intelligent Life | Peter Godfrey-Smith | HarperCollins |
| 2017 | Shortlist | To Be a Machine: Adventures Among Cyborgs, Utopians, Hackers, and the Futurists Solving the Modest Problem of Death | Mark O'Connell | Anchor |
| 2016 | Winner | The Invention of Nature: The Adventures of Alexander von Humboldt, the Lost Hero of Science | Andrea Wulf | Knopf |
| 2016 | Shortlist | Cure: A Journey Into the Science of Mind over Body | Jo Marchant | Crown |
| 2016 | Shortlist | The Gene: An Intimate History | Siddhartha Mukherjee | Scribner |
| 2016 | Shortlist | The Hunt for Vulcan: ... and How Albert Einstein Destroyed a Planet, Discovered Relativity, and Deciphered the Universe | Thomas Levenson | Head of Zeus |
| 2016 | Shortlist | The Most Perfect Thing: Inside (and Outside) a Bird's Egg | Tim Birkhead | Bloomsbury |
| 2016 | Shortlist | The Planet Remade: How Geoengineering Could Change the World | Oliver Morton | Princeton University Press |
| 2015 | Winner | Adventures in the Anthropocene: A Journey to the Heart of the Planet We Made | Gaia Vince | Milkweed Editions |
| 2015 | Shortlist | Alex Through the Looking-Glass: How Life Reflects Numbers and Numbers Reflect Life | Alex Bellos | Bloomsbury |
| 2015 | Shortlist | Life on the Edge: The Coming of Age of Quantum Biology | Johnjoe McFadden, Jim Al-Khalili | Transworld |
| 2015 | Shortlist | Life's Greatest Secret | Matthew Cobb | Basic Books |
| 2015 | Shortlist | Smashing Physics | Jon Butterworth | Headline |
| 2015 | Shortlist | The Man Who Couldn’t Stop | David Adam | Unknown |
| 2014 | Winner | Stuff Matters: The Strange Stories of the Marvellous Materials that Shape Our Man-made World | Mark Miodownik | Penguin Books |
| 2014 | Shortlist | Gulp: Adventures on the Alimentary Canal | Mary Roach | W. W. Norton |
| 2014 | Shortlist | Serving the Reich: The Struggle for the Soul of Physics under Hitler | Philip Ball | Vintage Books |
| 2014 | Shortlist | Seven Elements That Have Changed The World: Iron, Carbon, Gold, Silver, Uranium, Titanium, Silicon | John Browne | Orion |
| 2014 | Shortlist | The Cancer Chronicles: Unlocking Medicine's Deepest Mystery | George Johnson | Knopf |
| 2014 | Shortlist | The Perfect Theory: A Century of Geniuses and the Battle over General Relativity | Pedro G. Ferreira | Houghton Mifflin Harcourt |
| 2013 | Winner | The Particle at the End of the Universe | Sean Carroll | Oneworld |
| 2013 | Shortlist | Bird Sense | Tim Birkhead | Bloomsbury |
| 2013 | Shortlist | Cells to Civilizations: The Principles of Change That Shape Life | Enrico Coen | Princeton University Press |
| 2013 | Shortlist | Ocean of Life: The Fate of Man and the Sea | Callum Roberts | Viking |
| 2013 | Shortlist | Pieces of Light: The New Science of Memory | Charles Fernyhough | Profile Books |
| 2013 | Shortlist | The Book of Barely Imagined Beings | Caspar Henderson | University of Chicago Press |
| 2012 | Winner | The Information: A History, a Theory, a Flood | James Gleick | Fourth Estate |
| 2012 | Shortlist | Moonwalking with Einstein | Joshua Foer | Penguin Press |
| 2012 | Shortlist | My Beautiful Genome | Lone Frank | Oneworld |
| 2012 | Shortlist | The Better Angels of our Nature: A History of Violence and Humanity | Steven Pinker | Allen Lane |
| 2012 | Shortlist | The Hidden Reality | Brian Greene | Penguin Books |
| 2012 | Shortlist | The Viral Storm | Nathan Wolfe | Allen Lane |
| 2011 | Winner | The Wavewatcher's Companion | Gavin Pretor-Pinney | Bloomsbury |
| 2011 | Shortlist | Alex's Adventures in Numberland: Dispatches from the Wonderful World of Mathematics | Alex Bellos | Bloomsbury |
| 2011 | Shortlist | Massive: The Missing Particle That Sparked the Greatest Hunt in Science | Ian Sample | Basic Books |
| 2011 | Shortlist | The Disappearing Spoon | Sam Kean | Back Bay Books |
| 2011 | Shortlist | The Rough Guide to The Future | Jon Turney | Unknown |
| 2011 | Shortlist | Through the Language Glass: How Words Colour Your World | Guy Deutscher | Metropolitan Books |
| 2010 | Winner | Life Ascending | Nick Lane | W. W. Norton |
| 2010 | Shortlist | A World Without Ice | Henry Pollack | Avery |
| 2010 | Shortlist | Everyday Practice of Science: Where Intuition and Passion Meet Objectivity and Logic | Frederick Grinnell | Oxford University Press |
| 2010 | Shortlist | God's Philosophers: How the Medieval World Laid the Foundations of Modern Science | James Hannam | Unknown |
| 2010 | Shortlist | We Need To Talk About Kelvin | Marcus Chown | Unknown |
| 2010 | Shortlist | Why Does E=mc2? | Brian Cox, Jeff Forshaw | Unknown |
| 2009 | Winner | The Age of Wonder: How the Romantic Generation Discovered the Beauty and Terror of Science | Richard Holmes | HarperCollins |
| 2009 | Shortlist | Bad Science | Ben Goldacre | McClelland & Stewart |
| 2009 | Shortlist | Decoding the Heavens | Jo Marchant | Unknown |
| 2009 | Shortlist | The Drunkard's Walk: How Randomness Rules Our Lives | Leonard Mlodinow | Pantheon |
| 2009 | Shortlist | What the Nose Knows: The Science of Scent in Everyday Life | Avery Gilbert | Crown |
| 2009 | Shortlist | Your Inner Fish: A Journey Into the 3.5-Billion-Year History of the Human Body | Neil Shubin | Pantheon |
| 2008 | Winner | Six Degrees: Our Future on a Hotter Planet | Mark Lynas | Fourth Estate |
| 2008 | Shortlist | A Life Decoded, My Genome: My Life | J. Craig Venter | Viking |
| 2008 | Shortlist | Coral: A Pessimist in Paradise | Steve Jones | Little, Brown |
| 2008 | Shortlist | Gut Feelings | Gerd Gigerenzer | Unknown |
| 2008 | Shortlist | The Sun Kings: The Unexpected Tragedy of Richard Carrington and the Tale of How Modern Astronomy Began | Stuart Clark | Princeton University Press |
| 2008 | Shortlist | Why Beauty is Truth: A History of Symmetry | Ian Stewart | Basic Books |
| 2007 | Winner | Stumbling on Happiness | Daniel Gilbert | Knopf Canada |
| 2007 | Shortlist | Homo Britannicus | Chris Stringer | Unknown |
| 2007 | Shortlist | In Search of Memory: The Emergence of a New Science of Mind | Eric R. Kandel | W. W. Norton |
| 2007 | Shortlist | Lonesome George | Henry Nicholls | Macmillan |
| 2007 | Shortlist | One in Three | Adam Wishart | Grove Press |
| 2007 | Shortlist | The Rough Guide to Climate Change | Robert Henson | Unknown |
| 2006 | Winner | Electric Universe: How Electricity Switched on the Modern World | David Bodanis | Crown |
| 2006 | Shortlist | Collapse: How Societies Choose to Fail or Succeed | Jared Diamond | Unknown |
| 2006 | Shortlist | Empire of the Stars: Friendship, Obsession and Betrayal in the Quest for Black Holes | Arthur I. Miller | Little, Brown |
| 2006 | Shortlist | Parallel Worlds: The Science of Alternative Universes and our Future in the Cosmos | Michio Kaku | Knopf Doubleday Publishing Group |
| 2006 | Shortlist | Power, Sex, Suicide: Mitochondria and the Meaning of Life | Nick Lane | Oxford University Press |
| 2006 | Shortlist | The Truth About Hormones: What's Going on when We're Tetchy, Spotty, Fearful, Tearful or Just Plain Awful | Vivienne Parry | Atlantic Books |
| 2005 | Winner | Critical Mass: How One Thing Leads to Another | Philip Ball | Farrar, Straus and Giroux |
| 2005 | Shortlist | Matters Of Substance: Drugs - And Why Everyone's A User | Griffith Edwards | Allen Lane |
| 2005 | Shortlist | The Ancestor's Tale | Richard Dawkins | Unknown |
| 2005 | Shortlist | The Earth: An Intimate History | Richard Fortey | Unknown |
| 2005 | Shortlist | The Human Mind | Robert Winston | Bantam Books |
| 2005 | Shortlist | Why Life Speeds Up As You Get Older | Douwe Draaisma | Cambridge University Press |
| 2004 | Winner | A Short History of Nearly Everything | Bill Bryson | Random House |
| 2004 | Shortlist | Backroom Boys | Francis Spufford | Faber & Faber |
| 2004 | Shortlist | How to Clone the Perfect Blonde | Sue Nelson, Richard Hollingham | Unknown |
| 2004 | Shortlist | In The Beginning Was the Worm | Andrew Brown | Pocket Books |
| 2004 | Shortlist | Magic Universe | Nigel Calder | Oxford University Press |
| 2004 | Shortlist | Mutants: On Genetic Variety and the Human Body | Armand Marie Leroi | Penguin Books |
| 2004 | Shortlist | Nature Via Nurture | Matt Ridley | Harper Perennial |
| 2003 | Winner | Right Hand, Left Hand | Chris McManus | Phoenix |
| 2003 | Shortlist | Reckoning With Risk | Gerd Gigerenzer | Penguin Books |
| 2003 | Shortlist | Small World | Mark Buchanan | Weidenfeld & Nicolson |
| 2003 | Shortlist | The Blank Slate: The Modern Denial of Human Nature | Steven Pinker | Viking |
| 2003 | Shortlist | The Extravagant Universe | Robert P. Kirshner | Princeton University Press |
| 2003 | Shortlist | Where Is Everybody? | Stephen Webb | Springer Publishing Company |
| 2002 | Winner | The Universe in a Nutshell | Stephen Hawking | Unknown |
| 2002 | Shortlist | A Primate's Memoir | Robert M. Sapolsky | Scribner |
| 2002 | Shortlist | Aeons: The Search for the Beginning of Time | Martin Gorst | Fourth Estate |
| 2002 | Shortlist | Rivals: Conflict as the Fuel of Science | Michael White | Secker & Warburg |
| 2002 | Shortlist | The Madness of Adam and Eve: Did Schizophrenia Shape Humanity? | David Horrobin | Unknown |
| 2002 | Shortlist | The Secret Life of Dust | Hannah Holmes | Wiley |
| 2001 | Winner | Mapping the Deep | Robert Kunzig | W. W. Norton |
| 2001 | Shortlist | Creation: Life and How to Make It | Steve Grand | Weidenfeld & Nicolson |
| 2001 | Shortlist | Malignant Sadness | Lewis Wolpert | Faber & Faber |
| 2001 | Shortlist | Mendel's Demon | Mark Ridley | Phoenix |
| 2001 | Shortlist | Mendeleyev's Dream | Paul Strathern | Penguin Books |
| 2001 | Shortlist | Strange Beauty | George Johnson | Vintage Books |
| 2000 | Winner | The Elegant Universe: Superstrings, Hidden Dimensions, and the Quest for the Ultimate Theory | Brian Greene | W. W. Norton |
| 2000 | Shortlist | A Brief History of the Future | John Naughton | Unknown |
| 2000 | Shortlist | Children of Prometheus | Christopher Wills | Unknown |
| 2000 | Shortlist | Genome: The Autobiography of a Species in 23 Chapters | Matt Ridley | HarperCollins |
| 2000 | Shortlist | The White Death | Thomas Dormandy | Unknown |
| 2000 | Shortlist | Time, Love, Memory: A Great Biologist and His Quest for the Origins of Behavior | Jonathan Weiner | Faber & Faber |
| 1999 | Winner | The Man Who Loved Only Numbers | Paul Hoffman | Fourth Estate |
| 1998 | Winner | Guns, Germs, and Steel: The Fates of Human Societies | Jared Diamond | W. W. Norton |
| 1997 | Winner | The Wisdom of Bones | Alan Walker, Pat Shipman | Trafalgar Square Publishing |
| 1996 | Winner | Plague's Progress | Arno Karlen | Phoenix |
| 1995 | Winner | The Consumer’s Good Chemical Guide | John Emsley | Oxford University Press |
| 1994 | Winner | The Language of the Genes | Steve Jones | Flamingo |
| 1993 | Winner | The Making of Memory | Steven Rose | Transworld |
| 1992 | Winner | The Rise and Fall of the Third Chimpanzee | Jared Diamond | Vintage Books |
| 1991 | Winner | Wonderful Life: The Burgess Shale and the Nature of History | Stephen Jay Gould | W. W. Norton |
| 1990 | Winner | The Emperor's New Mind | Roger Penrose | Penguin Books |
| 1989 | Winner | Bones of Contention: Controversies in the Search for Human Origins | Roger Lewin | Simon & Schuster |
| 1988 | Winner | Living with Risk | British Medical Association Board of Science | Unknown |